Campus Collusion
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Lecture 4&5

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What are the functions of the immune system?
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1.Provide immunity 2.Distinguish foreign molecules from normal body cells 3.Help mediate inflammation 4. cancer surveillance
Name the componenets of the immune system.
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Immune cells Primary lymphoid organs: bone marrow and thymus Secondary lymphoid organs: spleen, lymph nodes, tonsils, appendix pyer's patches in intestines, mucosa=associated lymphoid tissues (MALT) in respiratory, GI, and reproductive systems
Explain innate immunity.
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First line defense. Responds quickly Controls microbial growth until adaptive immunity. Helps activate adaptive immunity.
Give examples of innate immunity.
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Skin and mucous membranes Phagocytic WBC's Natural killer cells cytokines Complement system
What is adaptive immunity?
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Specific/Acquired Second line defense Responds slowly More effective Acquired through exposure to infection/forein agents Targeted response to specific antigens
What cells are responsible for cellular/cell mediated immunity?
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CD4+ or helper Tcells CD8+ or cytotoxic Tcells Memory Cells
What type of Tcell is considered the "Master Switch" for adaptive immunity?
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CD4+ or helper Tcell.
How do CD8+ cells differ from NK cells?
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a)have to be activated by helper Tcells b)will only target specific antigen
What type of cells are believed to be a subset of CD8+ cells and what 2 actions are they responsible for
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Suppressor Tcells 1. stops the immune response once harmful/foreign agent is destroyed. 2. suppresses activity for self reactive immune cells (prevent autoimmune diseases)
What do memory cells do?
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Remain in body for a long time, enable more rapid response on repeat exposure (recognize antigen and stimulates T cell activity)
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IgG
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crosses placenta (only one that does) provides protection for newborns for first few months most plentiful in blood protects against past infection
IgA
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In body secretions. Protects mucous membranes.
IgM
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The first to appear in response to an antigen, it's presence usually suggests a current infection by pathogen.
IgD
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found on cell membrne of B lymphocytes, when binds with antigen it stimulates B cells to produce other specific Ig.
IgE
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involved in allergic reactions and parasitic infections.
Explain humoral/antibody- mediated immunity.
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When activated by helper Tcells, B lympocytes differentiate into: 1. plasma cells 2. memory cells
In humoral immunity what is the function of plasma cells?
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Secrete antibodies/Ig which bind to and aggregate antigens to aid in their removal by phagocytes (makes antibodies)
In humoral immunity what is the function of the memory cells?
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Upon subsequent exposure to an antigen, stimulatess production of plasma cells.
What does the presence of IgM indicate?
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Current infection
What Ig provides newborns with immunity?
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IgG
  
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