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Medication Administration BasicsMedical-Surgical Nursing-7th edition

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Protein-binding drugs need to be monitored in people with low _______.
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proteins (albumin)
LD 50/ ED 50 =
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TI
Water soluble drugs go _______ cells.
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in between
Oral drugs need to be _______ soluble.
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lipid
Binding agents in oral drugs...
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excipients
Disintegration and dissolution occur in the _______ phase.
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pharmaceutic
Food, GI transport time and lipid solubility all impact...
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absorption
_______ meds last a long time (weeks to months).
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Depo
Lipid soluble drugs go _______ cells.
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thru
What is the path of drugs affected by 1st pass ?
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Portal vein to across abdomen to liver (drug gets metabolized).
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Where does the majority of drugs undergo enzymatic alteration (metabolism)?
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The liver
GI transport time (including bowel issues, vomiting, diarrhea...) impacts _______.
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absorption
_______ soluble meds are administered via IV.
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Water
What are benefits of IV drugs?
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Almost instantaneously active, controlled, and can give meds that are otherwise irritable to the GI.
What are the negatives of IV meds?
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Costs and can be toxic from infiltrates.
What 3 enzymes of the Cytochrome P450 system metabolize drugs?
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CYPI/CYPIA2; CYP2/CYP206; and CYP3/CYP3A4.
What is a high first-pass effect?
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Most of a drug gets metabolized in the liver, rendering it useless.
Young and old people have a _______pH in the GI, which _______ drug absorption.
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high pH, slowing absorption
Intramuscular and SQ drugs are usually _______ soluble.
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water
What are the 4 categories of drug action?
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Stimulation/depression; Replacement (hormone, insulin); Inhibition /kill organism; Irritation (laxative).
Low TI = _______ toxic, High TI = _______ toxic
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low = more toxic, high = less toxic
  
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