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Oncological emergencies and cancer medsMedical-Surgical Nursing-7th edition

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Question Answer
_______ along the vein in which 5-FU is administered is a possible side effect of the drug.
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Hyperpigmentation
_______ is associated with cardiotoxicity.
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Doxorubicin
Antimetabolites affect the _______ phase of cell growth.
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S phase (DNA synthesis and metabolism)
G-CSF regulates the production of _______ within the bone marrow and uses include decreasing overall _______.
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neutrophils; infections
Filgrastin (Neupogen) initially causes a response in _______ after admin. A nadir occurs, a second peak occurs in _______ to _______ days.
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1st response in 24 hours; 2nd in 4-5 days. *Nadir = chemotherapy induced low point.
G-CSF like Neupogen are given via _______ and _______.
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IV or Sub Q
Proteins that stimulate growth and maturation of bone marrow stem cells...
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CSFs
What is the most common side effect of Filgrastim (Neupogen)?
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Bone pain
How do monoclonal antibodies work?
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They recognize proteins on specific cancer cells and are used to deliver drugs, toxins or radioactive material to cancer sites.
Mitotic Inhibitors work by blocking cell division at the _______ phase of the cell cycle.
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Mitotic Inhibitors = M phase
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Vinca alkaloids are derived from the _______.
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periwinkle plant (vinblastine, vincristine, vinorelbine, etc.)
The side effects of chemotherapy are largely related to _______.
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their toxic effect on normal cells
Vincristine and vinblastine are vinca alkaloids that may cause _______.
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reversible or irreversible neurotoxicity
What are signs and symptoms of vinca alkaloids?
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Decreased muscular strength, constipation, ptosis (drooping of upper eyelid), hoarseness, and motor instability).
Leucovorin rescue is common with _______.
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Methotrexate
What side effects of Cyclophosphamide is unique to African Americans?
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Hyperpigmentation of the tongue and oral mucosa.
CSFs can be administered both _______ and _______.
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IV and Sub Q
Tissue necrosis may occur _______ to _______ after the administration of Adriamycin/ doxorubicin.
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3-4 weeks
Neumega should be used within _______ of reconstitution. It should not be shaken.
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within 3 hours (*single dose vials)
Intron A is available as a _______ in _______, _______ and _______ million IU. Final concentrations after being mixed with H2O are:
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powder in 3,5 and 25 million IU; 3 million IU/vial (1 mL dilutant); 5 million IU/vial (2 mL dilutant); 25 million IU/vial (5 mL dilutant)
The dose limiting side effect of Roferon is _______.
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fatigue
  
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