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Oncological emergencies and cancer medsMedical-Surgical Nursing-7th edition

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The dose limiting side effect of Roferon is _______.
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fatigue
CCS are not active against cells _______.
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in the resting phase
Alkylating drugs disrupt cancer cells in what 3 ways?
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Causes cross-linking of DNA strands. Abnormal base pairing. DNA strand breaks. *Prevents cell from dividing.
Cancer patients on methotrexate (an antimetabolite) should be given _______ to rescue normal cells.
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leucovorin calcium
_______ status is the most important thing to assess prior to administering Adriamycin/doxorubicin.
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Cardiac
_______ of Rituximab should not be given to avoid hypersensitivities.
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IV bolus dose
What are the side effects of corticosteroids when used in cancer treatment?
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Fluid retention, K+ loss, increased risk of infection, increased blood sugar, and increased bleeding.
_______ is associated with neural toxicity.
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Vincristine
What is growth fraction?
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The number of cells proliferating in a tumor.
How do corticosteroids aid in the treatment of cancer?
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They retard the growth of cancerous tumors and suppress the inflammatory process. Cause a sense of well being and euphoria.
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Estrogen therapy is used to _______ in men and _______ in women.
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decrease progression of prostatic cancer in men; decrease growth of hormone dependent cancer in women
Proleukin should be permanently discontinued if _______ occur.
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organ toxicities like: tachycardia/ ventricular, arrhythmias, intubation (pulmonary), renal dysfunction/GI bleeding, coma, and seizures.
Cyclophosphamide _______ digoxin levels.
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lower
_______ and _______ drugs are often combined to maximize cell death.
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CCS; CCNS
Neumega stimulates growth of...
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platelets
What is Procrit used for and when is it started?
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Used to stimulate RBC production. Given when Hgb is less than 11. *Hematopoietic Growth Factor.
Neupogen/Neulasta are used to stimulate...
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WBC growth factors
A nadir is typically achieved within _______.
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7-10 days
Raloxifene (Evista) and Tamoxifen (Nolvadex) are _______ that slow tumor growth and work well in postmenopausal women.
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antiestrogens
Antimetabolites, Vinca alkaloids, Taxanes and Topoisomerase Inhibitors are _______ agents.
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Cell-Cycle Specific (CCS)
EPO, G-CSF and Neumega can be given together, but _______ should be used.
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different injection sites for each agent
  
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