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Oncological emergencies and cancer medsMedical-Surgical Nursing-7th edition

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Question Answer
EPO, G-CSF and Neumega can be given together, but _______ should be used.
Show Answer
different injection sites for each agent
_______ block conversion of androgens to estrogen.
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Aromatase Inhibitors
Doxorubicin is a powerful _______, it can cause _______ if it infiltrates tissues.
Show Answer
potent vesicant; causes necrosis (Adriamycin)
What are the 3 major functions of BRM's?
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Biologic Response Modifiers (BRM) 1. Enhance immunologic function. 2. Destroy/interfere tumor activities. 3. Promote differentiation of stem cells.
How does progestins help with breast, renal and endometrial cancers?
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They act by shrinking cancer tissues.
Roferon-A is available in _______ and _______ forms. Both should be _______ and used within _______.
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powder and liquid forms; refrigerate and use within one month
The antimicrotubules/taxanes group of drugs are produced from...
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procured from the needles and bark of the yew tree.
Fluorouracil is an antimetabolite that can _______ and has a _______ TI.
Show Answer
can cross blood-brain barrier; low TI = very toxic
CCS effects are expressed when _______ or _______ is attempted.
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cell repair or division
Herceptin is used to treat _______ that has tumors that overexpress _______.
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metastatic breast cancer; HER2 protein
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_______% of clients on Herceptin experience flu like symptoms.
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40
Chemotherapy is most effective against _______ tumors with a _______ growth fraction.
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small; increased
Why should cyclophosphamide be taken in the morning?
Show Answer
To prevent accumulation of the drug in the bladder over night. *Risk for hemorrhagic cystitis.
What are the top 3 cancers in men?
Show Answer
Prostate, lung, colorectal cancer.
What are the top 3 cancers in women?
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Breast, lung, colorectal cancer.
Antiemetics should be given _______ chemotherapy.
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before, during and after
What 3 ways can genes become cancerous?
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1. Proto-oncogenes mutates into an oncogene. It produces it's own growth proteins and grows uncontrolled. 2. Tumor suppressor genes becomes dysfunctional and allows cells to grow unchecked. 3. DNA repair genes are damaged and mutations aren't fixed/
The neurologic side effects of interferon are _______ and occur in ______% of patients on it.
Show Answer
reversible; 70%; (confusion, sleepy, transient, and memory loss)
Most patients on EPO will need supplements of _______.
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iron
CCNS drugs are _______ dependent and most effective by _______ because the # of cells affected is proportional to the amount given.
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dose dependent and is most effective as a bolus dose
Neumega is administered via _______ and dosing should begin within _______ to _______ after completion of chemo.
Show Answer
Sub Q; 6-24 hours of chemo
  
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