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Oncological emergencies and cancer medsMedical-Surgical Nursing-7th edition

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Page 7
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Cyclophosphamide is given by what routes of administration?
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Orally and IV.
CCNS drugs act during _______ of the cell cycle.
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any phase
CCS drugs exert their effects on cells _______ at specific phases throughout the cell cycle.
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actively dividing
_______ and _______ are 2 factors that play a major role in the response of cancer cells to anticancer drugs.
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Growth fraction and doubling time
What are the 10 general side effects of anticancer drugs?
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Anemia, neutropenia, thrombocytopenia, anorexia, n/v/d, mucositis, alopecia, fatigue, infertility, and organ toxicity.
What special things should be noted when giving EPO?
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Do not shake; Use only one dose per vial, discard the rest; Warm vial to room temperature before Sub Q; 1 mL or less per injection; and Use one needle to draw and another to inject.
How do aromatase inhibitors work?
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Block the peripheral conversion of androgens to estrogen, slowing tumor growth.
Which interferon is approved for cancer treatment?
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IFN-a
Procrit stimulates _______ in response to hypoxia.
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red blood cell production
Patients on interferon that experience neutropenia or thrombocytopenia should know that...
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the effects are reversible and dose dependent.
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Glycoprotein that regulates the production of neutrophils within bone marrow...
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GCSF
Antiandrogens like Eulexin (flutamide), Nilandron (nilutamide) and Casodex (bicalutamide) are useful in treating men with _______.
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hormone-responsive prostate cancer; block the effects of dihydrotestosterone
Anticancer drugs are more effective against neoplastic cells that have _______ growth fraction.
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high growth fraction
_______ have a large % of their cell mass in the G 0 phase, so they generally have a low growth fraction. They are _______ sensitive to drugs.
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solid tumors are less sensitive to drugs
The cardiopulmonary side effects of interferon are _______ related and occur more frequently in _______.
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dose related; occur more frequently in patients with existing heart problems or in the elderly
_______ has stomatitis as an early sign of toxicity.
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Fluorouracil
What is adjuvant therapy?
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Treating cancer with surgery then chemotherapy.
Neumega is a _______ growth factor and can potentially decrease _______.
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platelet; thrombocytopenia
What cells produce Interferon a?
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B cells, T cells, macrophages, and null cells.
CCNS drugs kill cells during the _______ and _______ phases. CCS drugs work best during the _______ phase.
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CCNS - M and G 0 phases; CCS - growth phase
Alkylating drugs, Nitrosources and Antitumor antibodies are _______ agents.
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Cell Cycle Nonspecific Agents (CCNS)
  
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